Fudan scientitsts of molecular and cell biology make new progress in research on occurrence and development of colon cancers


On May 1st, the Laboratory of Molecular Biology and Cell Biology (MCB) affiliated with the Biomedical Research Institute of Fudan published a research paper on Journal of Cancer Research entitled "Endothelin promotes colorectal tumorigenesis by activating YAP/TAZ" which concerns the signal transduction of metabolic post-translational modification and tumor cell biology. The first author of the work is Zhen Wang, the corresponding author being Kun-Liang Guan, Hai-Xin Yuan and Yue Xiong.

Colon cancer is the development of malignant tumors from the colon, which usually occurs with rectal cancer concurrently. Colon cancer is the second most common cancer in the world, ranking as the third among the types of cancer according to its death toll. Compared with normal tissues, colon carcinoma cells show a high level of endothelin receptor ETAR and features a new signaling pathway among cells.The signaling system plays an important role in the growth and migration of colon cancer cells and the growth of colon cancer xenografts.

The published study by the Laboratory illustrates the important role of the Hippo-YAP/TAZ signaling pathway mediated by endothelin, and the molecular mechanism of the activation of the endothelin receptor and its relation with colon cancer, providing a potentially new diagnostic and therapeutic target for the treatment of the disease and also laying the foundation for the application of Hippo pathway inhibitors. The study was funded by the National Natural Science Foundation and the NIH foundation.