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08 Dec 2019

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Lymphatic Endothelial Cells Promote the Self-renewal and immunologic escape of Hepatoma Stem Cells


The mechanism by which lymphatic endothelial cells help hepatoma stem cells to self-renew and escape immune attack has been recently revealed, according to the research published in Journal of Hepatology under the title “IL-17A Secreted from Lymphatic Endothelial Cells Promotes Tumorigenesis by Up-regulation of PD-L1 in Hepatoma Stem Cells”.

The research by Prof. Jiang Jianhai’s team from the School of Basic Medical Sciences of Fudan University sheds light on how the tumor microenvironment regulates hepatoma stem cells behavior and the role that N-glycans play in the process. 


Cancer stem cells (CSCs) are thought to be responsible for the initial development, progression and therapeutic resistance of tumors. The interaction between CSCs and the microenvironment is dependent on molecular recognition. The interactions between lectin and glycan play an important role in cell recognition and immune response.


Researchers have proved that lymphatic endothelial cells are an important component of the hepatoma stem cells microenvironment. The high-mannose type N-glycans mediate their interaction, thus promoting the self-renewal and immunologic escape of hepatoma stem cells. The research elucidates the mechanism by which the tumor microenvironment regulates hepatoma stem cells behavior and contributes to the development of targeted therapeutic approaches for hepatocellular carcinoma.


Associate Professor Wei Yuanyan, Shi Danfang and Liang Ziwei from the School of Basic Medical Sciences of Fudan University and Liu Yuming from Zhongshan hospital of Fudan University share the co-first authorship. Professor Jiang Jianhai and Associate Professor Wei Yuanyan are the corresponding authors.


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